"One pot" Microwave Assisted Synthesis of 5,10,15-Tri(4-Methoxyphenyl)- 20-( 4-Chlorophentyl)-21H,23H-Porphyrin and its Zinc (II) Complex.

Authors

  • Erika Loredo Calderón Universidad Autónoma de Nuevo León
  • Carolina Martínez Lejía Universidad Autónoma de Nuevo León
  • Susana López Cortina Universidad Autónoma de Nuevo León
  • Blanca Muñoz Flores Universidad Autónoma de Nuevo León
  • Eugenio Hernández Fernández Universidad Autónoma de Nuevo León
  • Víctor Jiménez Pérez Universidad Autónoma de Nuevo León
  • Erick Cuevas Yañez Universidad Nacional Autónoma de México

DOI:

https://doi.org/10.29105/qh2.2-136

Keywords:

one pot synthesis, unsymmetrical porphyrin, microwave irradiation

Abstract

Toe synthesis of new unsymmetrical A,B porphyrin, 5,10,15-tri(4-methoxyphenyl)-20-(4-chlorophenyl)-21H, 23H-porphyrin, 1, and its
Zinc(II) complex, 5, 1 O, 15-tri( 4-methoxyphenyl)-20-( 4-chlorophenyl)-21, 23- Zinc(II)-porphine, l, was accomplished using both conventional and "one pot" solventless microwave assisted methods with interesting comparative results. The obtained molecules were characterized by 'H NMR, UV-Vis and MS. These molecules are considered to represent new compounds with potential application as photosensitizers in
photodynamic therapy.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Author Biographies

Erika Loredo Calderón, Universidad Autónoma de Nuevo León

Facultad de Ciencias Químicas 

Carolina Martínez Lejía , Universidad Autónoma de Nuevo León

Facultad de Ciencias Químicas 

Susana López Cortina, Universidad Autónoma de Nuevo León

Facultad de Ciencias Químicas 

Blanca Muñoz Flores, Universidad Autónoma de Nuevo León

Facultad de Ciencias Químicas 

Eugenio Hernández Fernández , Universidad Autónoma de Nuevo León

Facultad de Ciencias Químicas 

Víctor Jiménez Pérez , Universidad Autónoma de Nuevo León

Facultad de Ciencias Químicas

Erick Cuevas Yañez , Universidad Nacional Autónoma de México

Centro Conjunto de Investigación en Química Sustentable

References

-[1] Kadish, K.; Smith, K. Handbook of Porphyrin Science. s.l. World Scientific Publising: USA, 2010; pp 360-428. DOI: https://doi.org/10.1142/7376-vol5

-[2] McDonald, A.; Franssen, N. J. Organomet. Chem. 2009, 694, 2153-2162. DOI: https://doi.org/10.1016/j.jorganchem.2009.02.020

-[3] Muthukumar, P.L; John, S. Sensors and Actuators, B: Chemical 2011, 159, 238-244. DOI: https://doi.org/10.1016/j.snb.2011.06.079

-[4] Banfi, S.; Caruso, E. J. Med. Chem. 2006, 49, 3293-3304. DOI: https://doi.org/10.1021/jm050997m

-[5] Fagadar-Cosma, E.; Cseh, L. Combinatoria! Chemistry & High Throughput Screening 2007, 10, 466-472. DOI: https://doi.org/10.2174/138620707781996385

-[6] Zoltan, T.; Vargas, F. Sci Pharm. 2010, 78, 767-789. DOI: https://doi.org/10.3797/scipharm.1003-13

-[7] Nguyen Q.; Olson E.; Aguilera T.; Jiang T.; Scadeng M. Proceedings ofthe Nationa!Academy ofSciences ofthe United StatesofAmerica2010, 107(9),4317-4322. DOI: https://doi.org/10.1073/pnas.0910261107

-[8] Pushpan, S.K.; Venkatraman, S. Curr. Med. Chem.- Anti Cancer Agents, 2002, 187. DOI: https://doi.org/10.2174/1568011023354137

-[9] Sachs R.; Brenner D. Proceedings ofthe National Academy of Sciences ofthe United States of America. 2005, 102, 13040-13045. DOI: https://doi.org/10.1073/pnas.0506648102

-[10] Boyle, R.W.; Dolphin, D. J. Photochem. Photobiol. 1996, 64, 469. DOI: https://doi.org/10.1111/j.1751-1097.1996.tb03093.x

-[11] Postino, F.; Mora, M.; DeMadariaga, M.A.; Nonell, S.; Sagrista, M.L Int. J. Pharma. 2004, 278, 239-254. DOI: https://doi.org/10.1016/j.ijpharm.2004.03.004

-[12] Scalise, l.; Durantini, E.N. J. Photochem. Photobiol. A 2004, 162, 105-113. DOI: https://doi.org/10.1016/S1010-6030(03)00317-4

-[13] Mac Donald, I.J.; Dougherty, T.J. J. Porphyrins Phthalocyanines 2001, 5, 105-129. DOI: https://doi.org/10.1002/jpp.328

-[14] Nyman, E.S.; Hynninen, P.H. J. Photochem. Photobiol. B 2004, 73, 1-28. DOI: https://doi.org/10.1016/j.jphotobiol.2003.10.002

-[15] Osterloh, J.; Vicente, M.G.H. J. Porphyrins Phthalocyanines 2002, 6, 305-325. DOI: https://doi.org/10.1142/S1088424602000373

-[16] Ricchelli, F.; Jori, G.; Gobbo, S.; Tronchin, M. Biochim. Biophys. Acta 1991, 1065, 4. DOI: https://doi.org/10.1016/0005-2736(91)90008-V

-[17] Lindsey J. S.; Schreiman I.C.; Hsu H.C.; Kearney P. C.; MarguerettazA. M. J. Org. Chem. 1987, 52, 827-836. DOI: https://doi.org/10.1021/jo00381a022

-[18] Yaseen, M.; Ali, M., Journal ofHeterocyclic Chemistry 2009, 46, 251-255. DOI: https://doi.org/10.1002/jhet.78

-[19] Krichhoff, M.; Ryan, M.A. Greener approaches to Undergraduate Chemistry Experiments, ACS: Washington, DC, 2002; pp 27-31.

-[20] Boscencu, R.; Socoteanu, R. Rev. Chim 2009, 60, 1006-1011.

Downloads

Published

2012-03-31

How to Cite

Loredo Calderón, E., Martínez Lejía , C., López Cortina, S., Muñoz Flores, B., Hernández Fernández , E., Jiménez Pérez , V. ., & Cuevas Yañez , E. (2012). "One pot" Microwave Assisted Synthesis of 5,10,15-Tri(4-Methoxyphenyl)- 20-( 4-Chlorophentyl)-21H,23H-Porphyrin and its Zinc (II) Complex . Quimica Hoy, 2(2), 6–9. https://doi.org/10.29105/qh2.2-136